
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

Steve and a tabloid reporter go undercover to find out who has been killing the residents of an idyllic community.

Mark helps an old nemesis escape a forced retirement by Capt. Newman by investigating a murder which resembles the work of the "Clown Killer."

Mark, Jesse and Amanda are among the guests present at an elegant hotel that has been deliberately contaminated with a deadly microbe.

To investigate a possible murder, Dr. Sloan goes into a house of roommates who are monitored 24 hours a day by cameras for a national television series.