
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

An accident involving a correctional bus brings prisoners to Community General, and a man convicted of murdering his wife takes Mark hostage.

Mark protects his kidnapper from police while trying to prove him innocent of his wife's murder, beginning a deadly chain reaction.

An overworked and tired Jesse witnesses the death of a patient, but when the body vanishes, not even Dr. Sloan believes him.

The high-pressure learning environment for the interns at the hospital claims Amanda's cousin, but Amanda believes his death is no accident.