
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

After a beautiful young surgeon with a frosty reputation prevents a distinguished doctor from performing surgery, she is found dead.

A paparazzo stays frames ahead of Dr. Sloan and Steve in a kidnapping investigation they believe is related to a murder; Amanda goes into labor.

When the administrator who threatened his career is murdered, Mark is a suspect and can clear his name only by committing a different murder.

Dr. Sloan tries to clean up the literary world when three lovely authors who penned a Hollywood tell-all book have their lives threatened.