
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

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Dr. Sloan uncovers a possible mother-daughter love triangle involving a country music star when he investigates the man's murder.
A woman recovering from the death of her husband becomes the chief suspect in the murder of her psychiatrist's wife when she is found next to the body.
When the wife of the hospital's new chief of staff is found murdered, Mark and Steve try to prove that it is the work of the woman stalking him.
Mark helps a radio host accused of murdering the woman who gave her up for adoption; Jesse is visited by his overbearing mother.