
Dr. Mark Sloan is chief of Internal Medicine at Community General Hospital -- and sometime consultant to the local police department. When he's drawn into a case, he combines sleuthing and medicine to solve the crime. That crime is usually one his detective son, Steve, is working on as a member of the local police department. Dr. Sloan's medical colleagues, including doctors Amanda Bentley, Jack Stewart and Jesse Travis, are also frequently drawn into his investigations.

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Dr. Sloan works with an international jewel thief (Stephanie Zimbalist) to solve the murder of a wealthy woman.
A teenager, wrongfully accused of murdering a gang leader, works with his older brother, Steve and Mark to find the real killer.
A prominent doctor is murdered, and three others are prime suspects; with Wayne Rogers; Chad Everett; Jack Klugman; Bernie Kopell.
Mark and Amanda race to cure a mysteriously ill pilot and his crew before the plane crashes into the Swiss Alps.