
After the unsolved murder of his wife, Adrian Monk develops obsessive-compulsive disorder, which includes his terror of germs and contamination. His condition costs him his job as a prominent homicide detective in the San Francisco Police Department, but he continues to solve crimes with the help of his assistant and his former boss.

Monk appears to have met his match when a fellow detective shows up at a crime scene knowing all the answers.

Natalie pursues a case while Monk is sick in bed with the flu.

Monk goes undercover as an office worker to solve the case of a killer who, targeting a financier, accidentally murders a parking attendant.

A relaxing getaway in wine country turns into a crime-filled weekend for Monk.