
A Florida team of forensics investigators uses cutting-edge scientific methods and old-fashioned police work to solve crimes. Horatio Caine, a former homicide detective, heads a group of investigators who work crimes amid the steamy tropical surroundings and cultural crossroads of Miami.

Marks on a female corpse on a beach lead Horatio to think the perpetrator is a serial killer who bites victims; Calleigh and Delko investigate a murder at a motel pool.

The team investigates when a fire engulfs a popular nightclub, killing 16 people and injuring 58 others.

The team delves into "tweaker" culture after a brutal murder is followed by a near-fatal explosion at the home of a methamphetamine addict.

Horatio witnesses a dramatic prison break and later discovers one of the escapees is a child molester/murderer he put away six months earlier.