Tom Selleck stars as Frank Reagan, the New York Police Commissioner, and patriarch of the Reagan clan, a multigenerational family of cops. Frank's oldest son is Danny, a seasoned detective and Iraqi War veteran who occasionally uses dubious tactics to solve cases. Daughter Erin, the lone female, is an assistant district attorney. Fresh out of Harvard Law, Jamie is the youngest member and "golden boy" of the family. Jamie gave up a lucrative future in law to continue the family's tradition in police work, and is asked to participate in a secretive investigation that even his father does not know about.

After Danny witnesses a drive-by shooting, he butts heads with the detective assigned to the case; a childhood friend of Jamie's is convinced that she has single-handedly solved a cold case murder.

Frank deals with a police captain who's losing his grip over his precinct; Danny faces backlash after a tough call he made in the field; Erin weighs the consequences of a dangerous criminal's release under new bail laws.

Eddie and her partner, Officer Rachel Witten, are heralded for their bravery for stopping an active shooter, until a civilian comes forward to accuse them of faking the incident as part of a government conspiracy.

Erin is conflicted by the weight of her authority in the sentencing of a man who is guilty of vehicular homicide; Danny and Baez pursue a rideshare rapist; Jamie and Eddie team up to aid a fellow officer when his partner is shot on the job.

Frank struggles after Joe Hill's lineage as a Reagan is revealed; Erin and Anthony receive gift-wrapped evidence; Danny's opposition to authority clashes with Jamie's adherence to the rules, as both brothers work to solve a murder.

Danny and Jamie combine forces to convict a notorious drug lord; Erin nervously awaits the governor's selection for the new district attorney; Frank and his grandson face a difficult decision as they navigate their new and complicated family ties.

Frank battles with City Council speaker Regina Thomas over protests against police brutality; Jamie and his nephew, Joe Hill, try to locate a missing Danny and Baez; Eddie helps an abrasive woman find her father's body.