
An elite squad of FBI profilers analyzes the country's most-twisted criminal minds, anticipating the perpetrators' next moves before they can strike again. Each member of the "mind hunter" team brings his or her expertise to pinpoint predators' motivations and identify emotional triggers to stop them. The core group includes an official profiler who is highly skilled at getting into the minds of criminals, a quirky genius, the former media liaison who manages to adeptly balance family life and the job, and a computer wizard.

When an unsub targets the BAU, the team pursues the person who is responsible for the actions.

The BAU works with the NSA when two undercover DEA agents are murdered and another goes missing; Hotch hopes the team's work with the NSA will bring them closer to finding a ring of hit men.

After a series of murders, Prentiss becomes suspicious of a former nemesis (Sebastian Roché) and fears for the safety of her team.

The members of the BAU team track an unknown subject who appears to be fascinated with medical experimentation.