
World's Most Evil Killers delves straight into the stories of the world's most prolific killers. Each episode focuses on one notorious killer and features first-hand accounts of their behavior; such killers range from Fred and Rose West, Ed Gein, the Clown Killer, to the Milwaukee Cannibal. Accounts are also given by detectives who ran the cases, journalists who reported on them, relatives, experts on analysis, and sometimes even survivors.

Sante and her son Kenneth Kimes are a murderous duo who killed three people in the 1990s; Sante Kimes fools victims across the U.S. during her outlandish 43-year crime spree.

American serial killer Richard Trenton Chase brutally murdered six people within one month.

Over four months during the late-70s, a killing duo terrorized LA by killing and dumping the bodies of ten women and girls as young as 12 on the city hillsides.

In the late 1980s, Bill Suff, aka the Riverside Prostitute Killer, is a model employee during the day, but, by night, he is a monster who lures sex workers into his van, where he stabs, strangles and mutilates them before dumping their bodies.