
A group of sisters discover they are witches. Luckily for the world, they're of the good variety. Banding together in their ancestral home in San Francisco, they work together to fight evil, with each having a specific special power. Although outwardly they are average women, with jobs, relationships and friends, they are also powerful witches, but when they work together, their powers are enhanced. As The Charmed Ones, their destiny is to protect innocents from evil.
Pandora's Box falls into the hands of a shape-shifting demon (Michelle Hurd) who intends to open it and release all of its sorrows into the world, sending the sisters on a search for Hope (Brooke Nevin).
A powerful sorceress (Suzanne Krull) casts a spell on Phoebe, so their souls switch bodies and Phoebe winds up trapped in the Underworld; Paige is in a quandary when her first charge (Seamus Dever) appears to be lost to the dark side.
The Charmed Ones do not realize that baby Wyatt's new imaginary friend is actually the demon Vicus, who is trying to win Wyatt's trust to convert him to evil.
When a classmate killed in front of Phoebe comes back from the dead to blame her, she becomes guilt-ridden and vulnerable, creating an opportunity for Zankou to steal the Book of Shadows.