
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A discarded sleeping bag, containing bloody sneakers and a purse, leads police to the body of a young woman; a mark found on the victim's body enables police to track the killer.

A look into the 1984 Oregon food poisonings, where detectives track down the outbreak to a cult which aims to use germ warfare to take down the government.

A girl who is abducted and then released soon afterward uses her knowledge of forensics to lead police to the kidnapper.

A woman is found dead from a gunshot wound and police suspect her husband, however, forensic teams prove what really happened, and the truth is stranger than fiction.