
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A 2-year-old boy's brain seizures and breathing problems baffle doctors until they learn the mother exhibits signs of Munchausen syndrome by proxy, a rare condition that led her to physically abuse her son and contributed to her daughter's death.

After a tycoon's wife is found dead in her SUV submerged in a half-frozen creek, police begin to suspect it wasn't an accident.

A speck of bicycle paint and a speck of nickel left over from a collision with a twice-convicted child molester's car provide critical clues in the murder of a 9-year-old.

A Russian immigrant is found dead and a strange phone call to his office is the only lead investigators have.