
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A mother is determined to discover what happened when her daughter is injured in a hit-and-run accident.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.

A woman heads home after church, but never makes it there alive, triggering a homicide investigation.

When a fundamentalist group is accused of robbing banks, authorities know they are dealing with experienced criminals and overwhelming evidence, but the defense is very well-funded.