
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Police in St. Petersburg, Fla., use cell phone mapping, wiretapping and a host of forensic evidence to find a surgeon's killer.

A 1995 fire razes the mansion of a Kansas doctor, killing two of her three children; disturbing accounts from an ex-husband lead investigators to believe the doctor set the blaze herself.

When a young boy has serious respiratory problems and his father shows signs of early Alzheimer's disease, a chance encounter with a stranger kicks off an investigation into the cause.

A husband confesses to his wife's murder, only to be found not guilty a year later when a phone tip and forensic evidence point to another.