
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A police officer claims his estranged wife's shooting death was a suicide, but investigators think it was a murder.

A woman who survived a deadly childhood fire sends police a letter charging that her father killed her mother 30 years ago.

A man tells police he shot an intruder who murdered his wife; forensic evidence leads police to re-examine the man's motives.

After more than 20 people on a Native American reservation die suddenly from a flu-like disease, Navajo medicine men provide a clue that leads to a most unlikely killer.