
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Hikers near Anchorage, Alaska discover a body wrapped in sheets edged in orange stitching; they discover threads of evidence clinging to the sheet.

Police become suspicious of a man who reported his wife missing 15 years after doing the same thing with his first wife.

The son of a murder victim contacts the police when a flight attendant is brutally murdered in a remarkably similar way.

The body of a young California co-ed under an isolated interstate ramp sets off an investigation; San Diego police have no idea who would want her dead, but they discover a tiny, unique fiber on the victim's clothing.