
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A son who is convinced of his mother's innocence in the death of his father enrolls in law school to try and clear her name.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.

The murder of a young Seattle couple puzzles investigators until the victims' dog, Chief, leads police to the killer.

A Russian immigrant is found dead and a strange phone call to his office is the only lead investigators have.