
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A wife is missing in Key West; investigators wonder if they should be searching for a missing person or a killer.

A mother is determined to discover what happened when her daughter is injured in a hit-and-run accident.

A son who is convinced of his mother's innocence in the death of his father enrolls in law school to try and clear her name.

When a farmer's wife disappears, the tests of a plant pathologist and a dendrochronologist lead to a surprising revelation.