
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A masked gunman kills two members of a family and wounds two others after they interrupt his burglary at their upscale suburban home.

When a woman's bone marrow test reveals arsenic poisoning, investigators try to determine if it is due to groundwater contamination or something more sinister.

The investigation of a murder case in New Jersey is stalled until a similar attack occurs on a state trooper in Maine.

After a woman is found dead at a yacht club in California in an apparent case of love gone wrong, investigators discover her home life was as dramatic as films made in nearby Hollywood.