
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Eight years after a man confessed to the murder of a young woman, another man claims that he committed the crime, and investigators must use forensic evidence to determine the true killer.

Arson investigators attempt to determine the cause of the 1987 fire at the Kings Cross Underground Station in London.

Two women who lived in the same apartment complex were brutally murdered; the similarities of the crime scenes led police to believe they were dealing with a serial killer who hated women, and they had to find him before he struck again.

The investigation of a murder case in New Jersey is stalled until a similar attack occurs on a state trooper in Maine.