
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a young woman goes missing on the way to the train station, investigators use a strand of hair and a bloody pillowcase to find a suspect.

When hunters find a skull in a Texas canyon, police find bits of clothing, a woman's shoe, some small bones and a strand of hair; once they discover her identity, it was time to find the killer.

A mother claims that an intruder murdered her two sons, but lacking a motive, police use blood-spatter analysis and behavioral profiling to reconstruct a different scenario.

A wife is missing in Key West; investigators wonder if they should be searching for a missing person or a killer.