
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When dozens of infants develop serious breathing problems in the Cleveland area, doctors and investigators search high and low for the cause.

A trash collector finds a severed human leg in a trash bin, but police cannot use conventional methods of victim identification; investigators turn to toxicology and DNA tests to find the murder-mutilator.

After a Vancouver custodian finds a burned body in a dumpster, investigators determine the corpse's identity and attacker.

Police find fragments of deleted computer files leading them to suspect a woman's suicide is really murder.