
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Four young adults are murdered in an affluent Texas neighborhood, with little evidence but two people walking by dressed in black.

The murder of a young Seattle couple puzzles investigators until the victims' dog, Chief, leads police to the killer.

A young college student is found dead in her apartment and the autopsy rules the death a homicide by an unknown male suspect.

A killer wants to outwit the police and keep the identity of his victim secret so he removes the teeth; however, lab tests on the skull reveal not just the horrific nature of the murder, but the identity of the victim too.