
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A missing bank president's body is found floating in a lake; the duct tape used in binding him to a chair helps solve the crime.
An anonymous caller reports the rape and murder of a dry cleaner employee; two eyewitnesses tell two similar but not identical stories.
A husband was shot and killed, forensic psychiatry helped the wife to remember the details for what happened.
Experts seek answers to a young businesswoman's death just before she was to testify in a criminal trial.