
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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The search for a missing exotic dancer led police to an isolated 75-acre site where someone had been shot and cremated, thus destroying all evidence... almost; piece of a foot provided enough DNA for a genetic profile and positive ID.
A husband confesses to his wife's murder, only to be found not guilty a year later when a phone tip and forensic evidence point to another.
When a man perishes in a fire while working in his garage, his death is initially ruled an accident until a forensic odontologist changes the direction of the case.
In Lorton, Va., police attempt to determine who abducted 5-year-old Melissa Brannen after she disappeared from a Christmas party, but cannot be certain until they match hair from a rabbit-fur jacket Brannen wore that day.