
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

In Lorton, Va., police attempt to determine who abducted 5-year-old Melissa Brannen after she disappeared from a Christmas party, but cannot be certain until they match hair from a rabbit-fur jacket Brannen wore that day.

A killer is careless when a home is destroyed by fire and a young boy is missing.

A husband confesses to his wife's murder, only to be found not guilty a year later when a phone tip and forensic evidence point to another.

A patrol officer is shocked by the amount of blood at a traffic accident and is shocked by the coroner's ruling until an anonymous phone call re-ignites the case.