
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A teenager goes missing after an evening of horseback riding; her body is found a month later, three miles from her home; the killer unknowingly leaves a trace of evidence behind, tiny but unmistakable clues that pointed to him and him alone.
Investigators unravel a twisted tale of lust, greed and deception after a woman claims her husband was gunned down by intruders.
Three seemingly unrelated deaths proved to be serial murders; the killer had been careful, he used poison which had no taste or odour; fortunately for investigators, it also has a unique chemical signature.
A man is murdered in his sleep but no fingerprints are anywhere to be found; a shoe impression outside could lead to the killer.