
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A woman is found dead from a gunshot wound and police suspect her husband, however, forensic teams prove what really happened, and the truth is stranger than fiction.

Hikers near Anchorage, Alaska discover a body wrapped in sheets edged in orange stitching; they discover threads of evidence clinging to the sheet.

A trash collector finds a severed human leg in a trash bin, but police cannot use conventional methods of victim identification; investigators turn to toxicology and DNA tests to find the murder-mutilator.

The son of a murder victim contacts the police when a flight attendant is brutally murdered in a remarkably similar way.