
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A trash collector finds a severed human leg in a trash bin, but police cannot use conventional methods of victim identification; investigators turn to toxicology and DNA tests to find the murder-mutilator.

A police officer claims his estranged wife's shooting death was a suicide, but investigators think it was a murder.

A girl who is abducted and then released soon afterward uses her knowledge of forensics to lead police to the kidnapper.

When firefighters find a family dead inside their home, it appears to be a murder-suicide; clues at the scene lead investigators to believe otherwise.