
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

In a small South Carolina town in 1991, 17-year-old Crystal Faye Todd, a popular high school student, is raped, murdered and dumped in a deserted field; with few leads, authorities test the DNA of several friends, and one match shocks everyone.

After a woman is found dead at a yacht club in California in an apparent case of love gone wrong, investigators discover her home life was as dramatic as films made in nearby Hollywood.

Two people witness a truck driving over an unconscious man and flee into a nearby bar, but when the police turn up, the truck, the man and the witnesses are gone.

The brutal murder of a state park employee over $2,000 rattles her co-workers and tourists while leaving police to sift through hundreds of leads.