
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Forensic science and deductive reasoning determine what happened to a mother and daughter while they were on a shopping spree.

When a doctor's wife disappears, investigators use concrete from the doctor's yard and the recollections of a child to determine what happened.

A convicted arsonist claims his innocence and with no lawyer, no money and only a fifth-grade education, sets out to prove it.

A canine behaviorist uses the family dogs, who are the only witnesses, to find the murderer of their owner.