
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A son who is convinced of his mother's innocence in the death of his father enrolls in law school to try and clear her name.

Police believe they have a serial rapist and murderer, but DNA testing and research leads to another arrest and conviction.

Blood spatter analysis and an investigation lead police to the truth when a pregnant woman is found dead in her home.

In 1976, 182 war veterans in Philadelphia become hospitalized with pneumonia-like symptoms and 29 die; the disease resurfaces every few years.