
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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California police in 1957 search for a murderer, but the case goes cold; 50 years after a crime is committed, advances in computer technology determine the killer.
An 11-year-old girl is sexually assaulted and shot twice at close range.
A man has no recollection of events after stabbing his wife and holding her head underwater in a swimming pool.
A woman is killed weeks before testifying against the man who sexually assaulted her.