
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A coroner finds telltale clues on the badly burned body of a murder victim, sending police in pursuit of a couple of killers.

When dozens of infants develop serious breathing problems in the Cleveland area, doctors and investigators search high and low for the cause.

A trash collector finds a severed human leg in a trash bin, but police cannot use conventional methods of victim identification; investigators turn to toxicology and DNA tests to find the murder-mutilator.

After a Vancouver custodian finds a burned body in a dumpster, investigators determine the corpse's identity and attacker.