
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A serial arsonist was on the loose in Washington, DC. Each of the fires was started with the same type of incendiary device. The perpetrator was very careful, and seemed to leave no evidence behind... but there were clues in the ashes, and it was up to forensic scientists to find them.
Wealthy man is shot dead while his wife is forced to open their hidden safe, but they couldn't be identified because they were wearing ski masks.
Investigators on both sides of the Atlantic seek links between three homicides that look like professional executions.
When an elderly woman dies in an apparent robbery-homicide, evidence suggests the suspect broke out of the house rather than breaking in.