
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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A twelve-year-old girl claims that she was abducted and sexually assaulted; her story seems unbelievable until police discover fibers on her clothing.
A man calls for help when his wife has a fatal fall down the stairs; numerous amount of bloodstains make police suspicious.
A decade old case reopens, and a few seconds of a 911 call enable investigators to determine who is responsible for a murder.
A flawed envelope is an unlikely clue to identifying a killer who laced a water cooler with cyanide and caused the death of a woman.