
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A son who is convinced of his mother's innocence in the death of his father enrolls in law school to try and clear her name.

The pornography empire cultivated by brothers Artie and Jim Mitchell crumbles when one turns up dead and his brother confesses to shooting him; investigators question whether the shooting was premeditated.

The investigation of a murder case in New Jersey is stalled until a similar attack occurs on a state trooper in Maine.

A young woman goes missing without leaving many clues, but the advanced technology on offer makes it possible for cat hairs and insects to help build an image of the abductor.