
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

After a prominent Arizona surgeon is found stabbed to death outside his office, investigators uncover an unlikely suspect with deep pockets and an even deeper hatred for the doctor.

The investigation of a murder case in New Jersey is stalled until a similar attack occurs on a state trooper in Maine.

Police don't have a basis for comparison to match shoe impressions, blood drops and DNA evidence from a murder scene.

When a 9-year-old girl vanishes on her way to school, the entire community helps with the search; detectives believe her mother may be involved, and a hidden fingerprint seals the case.