
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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When an elderly woman dies in an apparent robbery-homicide, evidence suggests the suspect broke out of the house rather than breaking in.
The bomb was constructed to cause as much damage as possible, and it did, killing the victim with deadly force and flame; a painstaking search yielded tiny clues, which identified the killer as surely as if he'd signed them.
A twelve-year-old girl claims that she was abducted and sexually assaulted; her story seems unbelievable until police discover fibers on her clothing.
A man calls for help when his wife has a fatal fall down the stairs; numerous amount of bloodstains make police suspicious.