
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A young bride-to-be is gunned down in her own home. The attack is personal and as investigators start digging, they uncover the man she loved was living a lie.

Two people witness a truck driving over an unconscious man and flee into a nearby bar, but when the police turn up, the truck, the man and the witnesses are gone.

Tara Munsey went missing after a work shift at a Virginia restaurant, and it is unknown if she ran away or if she was the victim of foul play.

After American Atheists founder Madalyn Murray O'Hair disappears, the discovery of a mutilated body helps police catch the culprit.