
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A woman who survived a deadly childhood fire sends police a letter charging that her father killed her mother 30 years ago.

In a small South Carolina town in 1991, 17-year-old Crystal Faye Todd, a popular high school student, is raped, murdered and dumped in a deserted field; with few leads, authorities test the DNA of several friends, and one match shocks everyone.

A woman is found dead on her bedroom floor, the only clue is a bloodstained sheet; breakthrough forensics enable police to identify the killer.

A beverage company pleads guilty to violating federal safety laws when a baby dies from E. coli after drinking apple juice.