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Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.
S8, EP11 "The Big Chill"
Officials probe the death of a woman investigating the possible side effects of the drug she was prescribed for bipolar disorder.
S5, EP17 "Second Shot at Love"
The apparent suicide of Dr. Darryl Sutorius, a respected heart surgeon, is questioned when an investigation reveals his new wife's violent history.
S9, EP21 "Deadly Matrimony"
Police become suspicious of a man who reported his wife missing 15 years after doing the same thing with his first wife.
S1, EP8 "The Wilson Murder"
After a wealthy Southern physician gets murdered with a baseball bat, his wife and a handyman become convicted of the crime.
S14, EP21 "Expert Witness"
A killer assaults a young mother in her home, but despite meticulous washing of the crime scene, a single hair remains to lead authorities to the culprit.
S14, EP20 "Funeral Services"
Police discover a mask near the crime scene and hope that it leads to the killer of a funeral director.
S14, EP19 "Skeleton Key"
A woman goes missing for a month with the only clues being a set of keys, a fingerprint and a code.
S14, EP17 "Seeing Red"
A body is found stuffed into a suitcase forcing the police to search though the landfill for another missing victim.