
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Investigators build a makeshift tent around a woman's body and use superglue fumes to lift the killer's palm print from the victim's skin.

A killer assaults a young mother in her home, but despite meticulous washing of the crime scene, a single hair remains to lead authorities to the culprit.

When a 6-year-old disappears, her father becomes the prime suspect; he fails a polygraph test and even confesses, but 10 years later, the investigation gets turned on its head.

The investigation into the disappearance of flight attendant Helle Crafts leads to the murder conviction of her pilot husband.