
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A wife is missing in Key West; investigators wonder if they should be searching for a missing person or a killer.

Suicide notes and a pistol in hand lead police to suspect that a mother of two young children appeared to have killed herself, but when investigators learned of a house fire she was in three years earlier, they reinvestigated.

The violent death of an Air Force officer's wife outside a Philippines air base is examined, amid accusations of a love triangle involving the murdered woman's husband; investigators use groundbreaking computer forensics to make their case.

At first glance it appears a young woman suffocated, but further investigation shows the scene was staged.