
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Ten years after the murder of a rock singer, forensic scientists use evidence collected to finally bring her killer to justice.

With children dying at an alarming rate at a Texas hospital, authorities narrow down their probe to one nurse, but the murder weapon remains elusive.

After a Michigan State University grad student disappears and is presumed dead, a professor of geological sciences helps police get the dirt on her killer.

Police charge Alan "The Zenith Man" Ridley with murdering his wife, Virginia, but following an autopsy, medical detectives believe he may not have killed his wife after all.