
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Heavy rains and snow run-off carry manure into Milwaukee's water supply in 1993, leading to an epidemic of gastrointestinal illness affecting 400,000 people.

A handsome young doctor's fiancée experiences severe illness after revealing that she is pregnant, and launches her own investigation to determine if the doctor is somehow responsible.

Autopsies reveal that a string of unexplained deaths in Omaha resulted from poison-induced liver disintegration.

Investigators build a makeshift tent around a woman's body and use superglue fumes to lift the killer's palm print from the victim's skin.