
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

The body of a young California co-ed under an isolated interstate ramp sets off an investigation; San Diego police have no idea who would want her dead, but they discover a tiny, unique fiber on the victim's clothing.

An Ohio woman and her two daughters go missing while vacationing in Florida; their corpses are found floating in Tampa Bay with a handwritten note by one of the victims; putting it on five billboards helps them find the killer.

The son of a murder victim contacts the police when a flight attendant is brutally murdered in a remarkably similar way.

Four young adults are murdered in an affluent Texas neighborhood, with little evidence but two people walking by dressed in black.