
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Two people witness a truck driving over an unconscious man and flee into a nearby bar, but when the police turn up, the truck, the man and the witnesses are gone.

Tara Munsey went missing after a work shift at a Virginia restaurant, and it is unknown if she ran away or if she was the victim of foul play.

After American Atheists founder Madalyn Murray O'Hair disappears, the discovery of a mutilated body helps police catch the culprit.

An Ohio woman and her two daughters go missing while vacationing in Florida; their corpses are found floating in Tampa Bay with a handwritten note by one of the victims; putting it on five billboards helps them find the killer.