
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

When a man dies unexpectedly in the office of a noted California doctor, police begin what they think will be a routine investigation, but discoveries of false identities and insurance fraud raise questions about the doctor's role.

A young girl beaten after watching her grandmother killed, identifies the wrong person; years later she tries to change her statement.

A mother puts her hope on the internet and an independent investigation to clear her name after authorities charge her with murdering her 17-month-old son in a fire considered to be intentionally set.

In 1984 police failed to convict the murderer of a college student; new technology may finally help the police to catch her killer.