
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

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Forensic investigators try to stop a killer who is apparently responsible for two slayings in a community in South Carolina.
When DNA proves that a man who practically admits to a brutal attack is innocent, police wonder why he is willing to take the blame.
When a businessman is murdered, motives and suspects are plentiful. Was it simply a disgruntled employee or client? Or do some racy photos hold the clue to the crime?
A family break turns into a nightmare when the wife is found face-down in a lake; with no idea whether it was murder, an accident or suicide, police turn to a new forensic technique.