
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

Autopsies reveal that a string of unexplained deaths in Omaha resulted from poison-induced liver disintegration.

Two women are murdered in the same town and police fear a serial killer is on the loose, further investigation finds that they were both close to the same man.

A young woman is found dead on a golf course in the Bahamas; the grass on that course is so distinctive that it had evidentiary value; the evidence leads police to two suspects; each blamed the other, and they have to find out who the killer is.

After the discovery of a skull in the forest near a boy scout camp, police use facial reconstruction to identify the body.