
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

There was no apparent reason for the young, healthy college student to be dead; but when the medical examiner found the tiniest of clues during the autopsy, investigators were able to unravel the mystery of betrayal and revenge.

When a farmer's wife disappears, the tests of a plant pathologist and a dendrochronologist lead to a surprising revelation.

A woman is stabbed a hundred times and her body positioned in a suggestive manner. This could be a hate crime against women.

The search for the killer of two teenagers in Texas shows a behavioral study on how most serial killers also have a history of abusing animals.