
Eagle-eyed technical experts prove there is no such thing as a perfect crime as they assemble the pieces every criminal leaves behind. Dramatic crime re-creations and, sometimes, part of the investigations are a staple of the series. Some of the re-creations include alternate versions of the crimes, which are disproved by science. The show's episodes follow each case from the initial investigation until it reaches its legal resolution.

A money launderer is found dead in the ocean and the only obvious clues to his identity are a Rolex watch and a tattoo; the anchor with which he is weighed down proves most helpful in solving the crime.

A used tissue, 12 years after the murder of a young Missouri woman, may be what cracks the case with a suspect list a mile long.

Investigators look into the shooting death of Russ Stager, a popular gym teacher, and discover that his death was not an accident; a message the victim recorded before his death reveals a story of greed.

When murder strikes a young girl, police quickly make an arrest, but cutting-edge technology from NASA proves they have the wrong suspect behind bars.